6 Click Chemistry: Mechanistic and Synthetic Perspectives 6 Ramesh Ramapanicker and Poonam Chauhan6. 6. 7 Copper–Catalyzed Azide Alkyne Cycloaddition (CuAAC) Click Reaction 76. 8 Ruthenium–Catalyzed Azide Alkyne Cycloaddition (RuAAC) Click Reactions 77 Applications of Click Chemistry in Drug Discovery and Development 75 Balasubramanian Gopalan and Kalpattu Kuppusamy Balasubramanian7. 7 Part A: Application of Click Chemistry to Drug Discovery and Development 75
Synthesis The click concept The Royal Society of Chemistry
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Are you sure you want to continue? In addition to carbene–promoted MCRs and frequently applied metal–catalyzed MCRs, it also covers recently developed catalytic enantioselective variants as well as MCR in drug discovery and for the synthesis of heterocyclic molecules and macrocycles. Edited by the leading experts and with a list of authors reading like a who′s who in multicomponent reaction chemistry, this is definitely a must–have for every synthetic organic chemist as well as medicinal chemists working in academia and pharmaceutical companies. Metal catalysis plays an increasingly important role in these reactions, often allowing several stereocenters to be selectively created and integrated in the target molecules.
Kobayashi and Jorgensen's handbook provides numerous examples of metal-catalyzed reactions, including [7+6], [8+7] and [9+7] cycloadditions. A large number of experimental procedures gives a concrete idea of the use of metal-catalyzed cycloaddition reactions in modern synthesis. The book is aimed at chemists in industry or academia, who want to effectively use cycloadditions in their work.