6 Click Chemistry: Mechanistic and Synthetic Perspectives 6 Ramesh Ramapanicker and Poonam Chauhan6. 6. 7 Copper–Catalyzed Azide Alkyne Cycloaddition (CuAAC) Click Reaction 76. 8 Ruthenium–Catalyzed Azide Alkyne Cycloaddition (RuAAC) Click Reactions 77 Applications of Click Chemistry in Drug Discovery and Development 75 Balasubramanian Gopalan and Kalpattu Kuppusamy Balasubramanian7. 7 Part A:
Synthesis The click concept The Royal Society of Chemistry
Previous article in issue Next article in issue Keywords Click chemistry Polysaccharide Chemical modification Hydrogel Drug delivery Olefin metathesis Choose an option to locate/access this article: Check if you have access through your login credentials or your institution. This action might not be possible to undo. Are you sure you want to continue? In addition to carbene–promoted MCRs and frequently applied metal–catalyzed MCRs, it also covers recently developed catalytic enantioselective variants as well as MCR in drug discovery and for the synthesis of heterocyclic molecules and macrocycles. Edited by the leading experts and with a list of authors reading like a who′s who in multicomponent reaction chemistry, this is definitely a must–have for every synthetic organic chemist as well as medicinal chemists working in academia and pharmaceutical companies. Metal catalysis plays an increasingly important role in these reactions, often allowing several stereocenters to be selectively created and integrated in the target molecules.
Kobayashi and Jorgensen's handbook provides numerous examples of metal-catalyzed reactions, including [7+6], [8+7] and [9+7] cycloadditions. A large number of experimental procedures gives a concrete idea of the use of metal-catalyzed cycloaddition reactions in modern synthesis. The book is aimed at chemists in industry or academia, who want to effectively use cycloadditions in their work. Please choose whether or not you want other users to be able to see on your profile that this library is a favorite of yours. You may have already requested this item. Please select Ok if you would like to proceed with this request anyway. WorldCat is the world's largest library catalog, helping you find library materials online.