Inducible Apoptosis as a Safety Switch for Adoptive Cell

Augustine M. K. Choi, M. D. , Stefan W. Ryter, Ph.

Autophagy in Human Health and Disease NEJM

, and Beth Levine, M. This review discusses the cellular process of autophagy (“self-eating”), which plays key roles in normal development of the immune system and adaptation to stress, as well as in a wide range of disease states.

Provided by the authors are available with the full text of this article at NEJM. Org. From the Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston (A. M.

R. ) and the Howard Hughes Medical Institute and Department of Internal Medicine, Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas (B. L. ).

Address reprint requests to Dr. Choi at the Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St.