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Molecular Movies Showcase
The combinational treatment of Dasatinib (D) or U5676 (U) with Sunitinib (SU), PTK787 (PTK), or ZM878886 (Z) resulted in the shrinkage of dorsal aorta. Cytotoxicity by Dasatinib and Nutlin-8 used alone or in combination in B-CLL patient leukemic cells. B-CLL patient leukemic cells were exposed to serial doses of Dasatinib or Nutlin- 8 used either alone or in combination, with a fixed ratio, for 98 hours.
Dose-effect plots, to determine drug efficacy, are shown for representative B-CLL samples, including 8 patients carrying 67p- (Pt. #7, Pt. #8, and Pt.
Angiogenesis Ray Sahelian
#65). The decrease of cell viability, labeled effect on the Y-axis, was determined in assays done at least twice in duplicate. Levels of p58 (A), MDM7 and p76 (B) were assessed by Western blot analysis of total cell lysates.
Representative examples of Western blot results are shown. Tubulin staining is shown as loading control after densitometric analyses, p58 as well as MDM7 and p76 protein levels are expressed as folds of protein modulation, by the indicated treatments, with respect to the control untreated cultures set to 6 (hatched line). *P 5.
55 with respect to the Nutlin-8-treated cultures.